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KMID : 0615720090260050085
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Jouranl of Korean Acupuncture and Moxibustion society
2009 Volume.26 No. 5 p.85 ~ p.94
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The Effect of Pharmacopuncture of Mori Cortex on Galactosamine-induced Liver Injury in Rats
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Wi Jun
Wei Tung-Sheun
Kim Jae-Hong
Yoon Yeo-Choong
Youn Dae-Hwan
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Abstract
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Objectives : This study was designed to investigate the effect of pharmacopuncture of Mori Cortex on galactosamine-induced liver injury in rats.
Methods : Male Sprague-Dawley rats were divided into 5 groups; Normal, liver injury not induced and not treated group. Control, the liver injury-induced and not treated group. Saline group, the liver injury-induced and saline injection at BL18. HA-1 and HA-2 group, the liver injury-induced and pharmacopuncture of Mori Cortex applied to BL18, each 1.3μg/g, 2.6μg/g. Then we observed the changes of γ-GTP, GOT, GPT, LDH, total cholesterol, triglyceride, total bilirubin.
Results : Pharmacopuncture of Mori Cortex treatment significantly inhibited the activities of γ-GTP, GOT, total cholesterol, triglyceride and total bilirubin in HA-1 group. γ-GTP, GTP, LDH, γ-GTP levels were significantly inhibited in HA-2 group.
Conclusions : These results demonstrate that the reduce of hepatic enzyme activation and lipid accumulation by pharmacopuncture of Mori Cortex may be by an antioxidant properties of Mori Cortex.
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KEYWORD
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Liver injury, galactosamine, pharmacopuncture, Mori Cortex
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